Mitochondrial Dysfunction

Guidelines | Symptom Management | Symptoms | Training | Treatment

Bateman Horne Clinical Care Guide for ME/CFS, Long COVID & Infection-Associated Chronic Conditions
BySteve 9 May 202510 May 2025

Released as version 1.0 today, a new and outstandingly comprehensive reference guide for both Doctors and Health Care Workers. The reference guide we needed 20 years ago! This certainly feels like an essential training reference:

“A Roadmap to Better Care:
Clinical Care Guide for ME/CFS, Long COVID &
Infection-Associated Chronic Conditions

Developed by the OMF-supported Medical Education Resource Center (MERC) at Bateman Horne Center, this resource offers a practical path forward—one grounded in clinical expertise, research, and the lived experience of patients”

https://batemanhornecenter.org/clinical_roadmap

Clinical-Care-Guide-First-Edition-2025-1

Direct link to download the guide PDF

Read More Bateman Horne Clinical Care Guide for ME/CFS, Long COVID & Infection-Associated Chronic Conditions
Health Services | Symptom Management | Symptoms | Treatment | Videos

Fatigue, Mitochondria and the Energy Puzzle
BySteve 5 May 2025

The latest video from Dr. Sanjay Gupta shows true compassion for those suffering from ME, Long Covid and POTS. More selected videos from Dr. Sanjay Gupta can be found here.

Fatigue, Mitochondria and the Energy Puzzle

Dr. Sanjay Gupta explores mitochondrial dysfunction as a cause for unexplained long term fatigue, brain fog, post-exertional malaise and temperature dysregulation

Read More Fatigue, Mitochondria and the Energy Puzzle
Diagnostic Measurements | Research Papers | Symptoms

New Abstract on invasive CPET – Promising outcomes
BySteve 5 May 20255 May 2025

The American Journal of Respiratory and Critical Care Medicine has posted a new abstract authored by David Systrom et al, which evaluated invasive CPET testing. The test includes iCPET results from 438 ME/CFS patients, 73 Long Covid patients, and 43 symptomatic but otherwise normal controls.

The measurement method is illustrated here from their previous 2023 report [TBA]

The full Abstract within the American Journal of Respiratory and Critical Care Medicine can be found here: https://www.atsjournals.org/doi/abs/10.1164/ajrccm.2025.211.Abstracts.A7881

An image extract from the article is shown below, showing correlation of pVO2 between each cohort and outcomes, and remarkably similar results from ME and Long Covid:

Read More New Abstract on invasive CPET – Promising outcomes
Media

Long Covid : Relapse linked to sugar or effort
BySteve 5 April 2025

Article from “French Daily News” claims “In conclusion, excess glucose can trigger a late relapse (24 to 48 hours later) due to purinergic receptor activation and energy depletion.”

The content does seems more appropriate for a medical journal than a daily paper!

Long Covid : relapse linked to sugar or effort

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Research Papers | Videos

The Latest Research on Mitochondrial Dysfunction in Long Covid & ME/CFS | With Prof. Klaus Wirth
BySteve 23 March 202525 March 2025

Gez Medinger talks with Prof. Klaus Wirth about his research into Mitochondrial Dysfunction, particularly in relation to intramuscular sodium levels. He reassures us that intramuscular sodium levels are not influenced by additional salt intake typically used to increase blood volume, for those suffering from orthostatic intolerance or POTS.

Part 2 looks at use of a potential new drug, referred to as MDC002:

Read More The Latest Research on Mitochondrial Dysfunction in Long Covid & ME/CFS | With Prof. Klaus Wirth

Fatigue, Mitochondria and the Energy Puzzle